In the State of São Paulo—home to Latin America’s largest industrial complex and a strong scientific and technological base—green hydrogen and other low-carbon pathways represent not only a route toward decarbonization but also an opportunity to participate in emerging global value chains. This panel will discuss how São Paulo can structure its low-carbon hydrogen strategy by leveraging its renewable energy potential, considering ongoing initiatives, cooperation instruments with other countries and multilateral organizations, regulatory and financial challenges, and opportunities for innovation and the creation of high-skilled jobs.